Verruciform xanthoma in the hard palate: a case report and literature review
Identifieur interne : 000935 ( Main/Exploration ); précédent : 000934; suivant : 000936Verruciform xanthoma in the hard palate: a case report and literature review
Auteurs : Alexandre Sim Es Garcia [Brésil] ; Otávio Pagin [Brésil] ; Paulo Sérgio Da Silva Santos [Brésil] ; Denise Tostes Oliveira [Brésil]Source :
- Journal of the Korean Association of Oral and Maxillofacial Surgeons [ 2234-7550 ] ; 2016.
Abstract
Oral verruciform xanthoma (OVX) is an uncommon lesion that appears on the oral mucosa. The aim of this paper was to discuss the probable etiopathogenesis of OVX in the hard palate, reinforcing the importance of including this lesion in the differential diagnosis of verrucous lesions. A 43-year-old male smoker presented with a painless lesion with a verrucous surface and erythematous spots on the hard palate. Excisional biopsy revealed oral mucosa consisting of hyperkeratosis, acanthosis, and elongated rete pegs. Subjacent connective tissue showed numerous foam cells with clear cytoplasm and pyknotic nucleus, negative on periodic acid-Schiff staining. Immunohistochemical analysis revealed foam cells positive for anti-CD68 antibody, while anti-KI-67 antibody was restricted to the basal layer of the oral epithelium. A final diagnosis of OVX was established. The patient showed no signs of recurrence after seven months of follow-up. Physical trauma and smoking habits can be directly related to the etiology of verruciform xanthoma because the lesion is chronic and inflammatory with slow growth, and sites if high trauma are more often affected by such a lesion. The hard palate is the second most commonly affected site, and local trauma caused by smoking can be a cause of this type of lesion.
Url:
DOI: 10.5125/jkaoms.2016.42.6.383
PubMed: 28053911
PubMed Central: 5206246
Affiliations:
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of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru</wicri:regionArea><orgName type="university">Université de São Paulo</orgName><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Pagin, Otavio" sort="Pagin, Otavio" uniqKey="Pagin O" first="Otávio" last="Pagin">Otávio Pagin</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru</wicri:regionArea><orgName type="university">Université de São Paulo</orgName><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Da Silva Santos, Paulo Sergio" sort="Da Silva Santos, Paulo Sergio" uniqKey="Da Silva Santos P" first="Paulo Sérgio" last="Da Silva Santos">Paulo Sérgio Da Silva Santos</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru</wicri:regionArea><orgName type="university">Université de São Paulo</orgName><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Oliveira, Denise Tostes" sort="Oliveira, Denise Tostes" uniqKey="Oliveira D" first="Denise Tostes" last="Oliveira">Denise Tostes Oliveira</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru</wicri:regionArea><orgName type="university">Université de São Paulo</orgName><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author></analytic><series><title level="j">Journal of the Korean Association of Oral and Maxillofacial Surgeons</title><idno type="ISSN">2234-7550</idno><idno type="eISSN">2234-5930</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Oral verruciform xanthoma (OVX) is an uncommon lesion that appears on the oral mucosa. The aim of this paper was to discuss the probable etiopathogenesis of OVX in the hard palate, reinforcing the importance of including this lesion in the differential diagnosis of verrucous lesions. A 43-year-old male smoker presented with a painless lesion with a verrucous surface and erythematous spots on the hard palate. Excisional biopsy revealed oral mucosa consisting of hyperkeratosis, acanthosis, and elongated rete pegs. Subjacent connective tissue showed numerous foam cells with clear cytoplasm and pyknotic nucleus, negative on periodic acid-Schiff staining. Immunohistochemical analysis revealed foam cells positive for anti-CD68 antibody, while anti-KI-67 antibody was restricted to the basal layer of the oral epithelium. A final diagnosis of OVX was established. The patient showed no signs of recurrence after seven months of follow-up. Physical trauma and smoking habits can be directly related to the etiology of verruciform xanthoma because the lesion is chronic and inflammatory with slow growth, and sites if high trauma are more often affected by such a lesion. The hard palate is the second most commonly affected site, and local trauma caused by smoking can be a cause of this type of lesion.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Shafer, Wg" uniqKey="Shafer W">WG Shafer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hegde, U" uniqKey="Hegde U">U Hegde</name></author><author><name sortKey="Doddawad, Vg" uniqKey="Doddawad V">VG Doddawad</name></author><author><name sortKey="Sreeshyla, H" uniqKey="Sreeshyla H">H Sreeshyla</name></author><author><name sortKey="Patil, R" uniqKey="Patil R">R Patil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zegarelli, Dj" uniqKey="Zegarelli D">DJ Zegarelli</name></author><author><name sortKey="Zegarelli Schmidt, Ec" uniqKey="Zegarelli Schmidt E">EC Zegarelli-Schmidt</name></author><author><name sortKey="Zegarelli, Ev" uniqKey="Zegarelli E">EV 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Sérgio Da Silva Santos</name><name sortKey="Oliveira, Denise Tostes" sort="Oliveira, Denise Tostes" uniqKey="Oliveira D" first="Denise Tostes" last="Oliveira">Denise Tostes Oliveira</name><name sortKey="Pagin, Otavio" sort="Pagin, Otavio" uniqKey="Pagin O" first="Otávio" last="Pagin">Otávio Pagin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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